Benepali  Pen



  • This is the BenepaliTM single-dose, autoinjector pen.
  • There is no button to press. Just press the whole pen down firmly on the injection site and the injection starts automatically.
  • The needle is hidden below the blue needle cap.


The Benepali pre-filled pen is for a subcutaneous injection. It should be injected into the thigh, abdomen, or back of the upper arm

Rotate the site for each injection.

If you are injecting into the abdomen, choose a site that is at least 5 cm away from the belly button.

  • Do not inject into areas that are red, hard, bruised, or tender.
  • Do not inject into scars or stretch marks.
  • If you have psoriasis, do not inject into any raised, thick, red, or scaly skin patches, or lesions.


  1. 1. Inspect the pre-filled pen:

    Check the expiry date on the pre-filled pen label.

    • Do not use the pre-filled pen past the expiration date.
    • Do not use the pre-filled pen if it has been dropped onto a hard surface. Components inside the pre-filled pen may be broken.
    • Do not use the pre-filled pen if the needle cap is missing or not securely attached.
  2. 2. Inspect the solution:

    Look at the medicine through the viewing window. The medicine should be clear to slightly opalescent, colourless or pale yellow, and may contain small white or almost transparent particles of protein.

    • Do not use the solution if it is discoloured, cloudy, or if particles other than those described above are present.
  3. 3. Allow the medicine to reach room temperature:

    Remove one pre-filled pen from the carton that is stored in the refrigerator and leave at room temperature for at least 30 minutes before injecting.

    This is important to make the medicine easier and more comfortable to inject.

    • Do not remove the needle cap until you are ready to inject.
    • Do not use heat sources, such as a microwave or hot water, to warm Benepali.


Step 1.

Wash hands

Use soap and water.

Step 2.

Clean injection site

Wipe the skin at the injection site with an alcohol swab.

Do not touch this area again before injecting.

Step 3.

Remove needle cap

Pull the blue needle cap straight off.

Do not twist or bend the blue needle cap while removing it, as this may damage the needle.

Never recap the needle.

Dispose of cap in the sharps container.

Step 4.

Position the pen

Position the BenepaliTM pen at approximately 90 degrees to the skin.

Do not pinch the skin.

Step 5.

Press firmly to start

Firmly press the BenepaliTM pen and press down into the site to start the injection (there is no button to push).

The pen may first click when the injection begins - do not lift the pen up yet.

Continue to hold the pen firmly pressed into the site

You may hear a second click.

Step 6.

Count to 15 after 2nd click

Once you hear the second click, count slowly to 15 while continuing to press into the injection site to ensure the injection is complete.

Do not release pressure against the injection site or move the BerepaliTM pen before injection is complete.

Step 7.

Remove and confirm

Lift empty pen off skin. The needle guard should completely cover the needle.

Check that the yellow plunger rcc extends through the viewing window to confirm that the full dose has been delivered.

Step 8.

Dispose of pen properly

Throw away the used pen in a special container as instructed by your doctor, nurse or pharmacist.

Do not throw the sharps container in household bin nor recycle it.

Always keep the container out of the sight and reach of children.

lnjection site care

If there is bleeding at the injection site, press a gauze pad over the injection site.

• Do not rub the injection site.

If needed, cover the injection site with a plaster.